FR 901451, a novel inhibitor of human leukocyte elastase from Flexibacter sp. II. Pharmacological effect of FR 901451.
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منابع مشابه
The HST view of the FR I / FR II dichotomy ⋆
In order to explore how the FR I / FR II dichotomy is related to the nuclear properties of radio galaxies, we studied a complete sample of 26 nearby FR II radio galaxies using Hubble Space Telescope (HST) images and compared them with a sample of FR I previously analyzed. FR I nuclei lie in the radio-optical luminosity plane along a tight linear correlation, which argues for a common synchrotro...
متن کاملFR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics.
FR-900520 and FR-900523, novel neutral macrolide immunosuppressants, were isolated from the cultured broth of Streptomyces hygroscopicus subsp. yakushimaensis No. 7238. Their molecular formulae were determined as C43H69NO12 and C42H67NO12, respectively. The compounds suppressed immune response in vitro. IC50 values of FR-900520 and FR-900523 for mouse mixed lymphocyte reaction were 0.55 nM and ...
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characterized by its gray aerial mycelium color, hygroscopic spore mass and spiral spore chains with warty or spiny spore surfaces. It is nonchromogenic. Strain No. 7238 shows characteristics most closely related to Streptomyces antimycoticus and S. hygroscopicus, although there are differences in physiological characteristics and carbohydrate utilization. In terms of morphological characterist...
متن کاملJet/environment Interactions of Fr-i and Fr-ii Radio Galaxies
We present the results of new XMM observations of FR-I and FR-II radio galaxies that show the importance of jet/environment interactions for both radiosource structure and the properties of the surrounding gas. The FR-I observations reveal that the distribution of hot gas determines the radio-lobe morphology, and provide evidence that the subsonic expansion of the lobes heats the surrounding ga...
متن کاملAntibiotics from basidiomycetes. X. Scorodonin, a new antibacterial and antifungal metabolite from Marasmius scorodonius (Fr.) Fr.
Scorodonin (1), a novel biologically active metabolite, was isolated from submerged cultures of the mushroom Marasmius scorodonius (FR.) FR. Its structure has been determined by chemical and physical methods. The antibiotic inhibits the growth of bacteria, yeasts, and filamentous fungi. In cells of the ascitic form of EHRLICH carcinoma the incorporation of thymidine and uridine into DNA and RNA...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1994
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.47.1365